Anti-ATP1B1 antibody (STJA0006957)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ATP1B1
General Information
| Short Description | Rabbit polyclonal anti-Sodium/potassium-transporting ATPase subunit beta-1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATP1B1 |
| Gene ID | 481 |
| Uniprot ID | AT1B1_HUMAN |
| Immunogen | Synthesized peptide derived from human ATP1B1 |
| Specificity | This antibody detects endogenous levels of ATP1B1 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Glutathionylated. N-glycosylated. |
| Function | This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1. Involved in cell adhesion and establishing epithelial cell polarity. |
| Protein Name | Sodium/Potassium-Transporting Atpase Subunit Beta-1Sodium/Potassium-Dependent Atpase Subunit Beta-1 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell MembraneSarcolemmaColocalizes With Obscn At The Intercalated Disk And Sarcolemma In CardiomyocytesLocalizes In Long Striations At The Level Of Z And M Lines |
| Alternative Antibody Names | Anti-Sodium/Potassium-Transporting Atpase Subunit Beta-1 antibodyAnti-Sodium/Potassium-Dependent Atpase Subunit Beta-1 antibodyAnti-ATP1B1 antibodyAnti-ATP1B antibody |
Information sourced from Uniprot.org