Anti-ATP1A1 antibody (1-1023) (STJ110188)

Name: Anti-ATP1A1 antibody (1-1023) (STJ110188)
SKU: STJ110188
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ110188

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Short Description	Rabbit polyclonal Na+/K+-ATPase (1-1023) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:100-1:500 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	ATP1A1
Gene ID	476
Uniprot ID	AT1A1_HUMAN
Immunogen Region	1-1023
Immunogen Sequence	MGKGVGRDKYEPAAVSEQGD KKGKKGKKDRDMDELKKEVS MDDHKLSLDELHRKYGTDLS RGLTSARAAEILARDGPNAL TPPPTTPEWIKFCRQLFGGF
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human Na+/K+-ATPase (NP_000692.2).

Post Translational Modifications	Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity.
Function	This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis.
Protein Name	Sodium/Potassium-Transporting Atpase Subunit Alpha-1 Na(+/K(+ Atpase Alpha-1 Subunit Sodium Pump Subunit Alpha-1
Database Links	Reactome: R-HSA-5578775 Reactome: R-HSA-936837 Reactome: R-HSA-9679191
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Sarcolemma Cell Projection Axon Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Antibody Names	Anti-Sodium/Potassium-Transporting Atpase Subunit Alpha-1 antibody Anti-Na(+/K(+ Atpase Alpha-1 Subunit antibody Anti-Sodium Pump Subunit Alpha-1 antibody Anti-ATP1A1 antibody

Information sourced from Uniprot.org