• Western blot analysis of lysates from PC-12 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-ATP10A antibody (1129-1179 aa) (STJ194525)

SKU:
STJ194525

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospholipid-transporting ATPase VA (1129-1179 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ATP10A
Gene ID: 57194
Uniprot ID: AT10A_HUMAN
Immunogen Region: 1129-1179 aa
Specificity: This antibody detects endogenous levels of AT10A at Human/Mouse
Immunogen: Synthesized peptide derived from the human AT10A at the amino acid range 1129-1179
Post Translational Modifications Autophosphorylated at the conserved aspartate of the P-type ATPase signature sequence.
Function Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. Initiates inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking. Facilitates ITGB1/beta1 integrin endocytosis, delaying cell adhesion and cell spreading on extracellular matrix. Has low flippase activity toward glucosylceramide (GlcCer).
Protein Name Phospholipid-Transporting Atpase Va
Atpase Class V Type 10a
Aminophospholipid Translocase Va
P4-Atpase Flippase Complex Alpha Subunit Atp10a
Database Links Reactome: R-HSA-936837
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Exit From The Endoplasmic Reticulum Requires The Presence Of Tmem30a
But Not That Of Tmem30b
Alternative Antibody Names Anti-Phospholipid-Transporting Atpase Va antibody
Anti-Atpase Class V Type 10a antibody
Anti-Aminophospholipid Translocase Va antibody
Anti-P4-Atpase Flippase Complex Alpha Subunit Atp10a antibody
Anti-ATP10A antibody
Anti-ATP10C antibody
Anti-ATPVA antibody
Anti-ATPVC antibody
Anti-KIAA0566 antibody

Information sourced from Uniprot.org

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