Anti-ATIC antibody [3H12-C9-H9] (STJA0038218)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant human ATIC protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-ATIC for use in WB in Human, Mouse, Monkey and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human/Mouse/Monkey/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3H12-C9-H9 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 4.7 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ATIC |
| Gene ID | 471 |
| Uniprot ID | PUR9_HUMAN |
| Immunogen | Purified recombinant human ATIC protein fragments expressed in E.coli. |
Additional Info
| Tissue Specificity | Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas. |
| Function | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. |
| Protein Name | Bifunctional Purine Biosynthesis Protein AticAicar Transformylase/Inosine Monophosphate CyclohydrolaseAtic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase5-Aminoimidazole-4-Carboxamide Ribonucleotide FormyltransferaseAicar FormyltransferaseAicar Transformylase - Inosine 5'-Monophosphate CyclohydrolaseImp CyclohydrolaseImp SynthaseInosinicase |
| Database Links | Reactome: R-HSA-73817Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Bifunctional Purine Biosynthesis Protein Atic antibodyAnti-Aicar Transformylase/Inosine Monophosphate Cyclohydrolase antibodyAnti-Atic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase antibodyAnti-5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase antibodyAnti-Aicar Formyltransferase antibodyAnti-Aicar Transformylase - Inosine 5'-Monophosphate Cyclohydrolase antibodyAnti-Imp Cyclohydrolase antibodyAnti-Imp Synthase antibodyAnti-Inosinicase antibodyAnti-ATIC antibodyAnti-PURH antibodyAnti-OK antibodyAnti-SW-cl.86 antibody |
Information sourced from Uniprot.org