| Host: |
Mouse |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Bifunctional purine biosynthesis protein ATIC is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
3H12-C9-H9 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATIC |
| Gene ID: |
471 |
| Uniprot ID: |
PUR9_HUMAN |
| Specificity: |
This antibody detects endogenous levels of ATIC and does not cross-react with related proteins. |
| Immunogen: |
Purified recombinant human ATIC protein fragments expressed in E.coli. |
| Function | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. |
| Protein Name | Bifunctional Purine Biosynthesis Protein AticAicar Transformylase/Inosine Monophosphate CyclohydrolaseAtic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase5-Aminoimidazole-4-Carboxamide Ribonucleotide FormyltransferaseAicar FormyltransferaseAicar Transformylase - Inosine 5'-Monophosphate CyclohydrolaseImp CyclohydrolaseImp SynthaseInosinicase |
| Database Links | Reactome: R-HSA-73817Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Bifunctional Purine Biosynthesis Protein Atic antibodyAnti-Aicar Transformylase/Inosine Monophosphate Cyclohydrolase antibodyAnti-Atic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase antibodyAnti-5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase antibodyAnti-Aicar Formyltransferase antibodyAnti-Aicar Transformylase - Inosine 5'-Monophosphate Cyclohydrolase antibodyAnti-Imp Cyclohydrolase antibodyAnti-Imp Synthase antibodyAnti-Inosinicase antibodyAnti-ATIC antibodyAnti-PURH antibodyAnti-OK antibodyAnti-SW-cl.86 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
