Anti-ATIC antibody (1-300) (STJ27505)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ATIC (1-300) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATIC |
| Gene ID | 471 |
| Uniprot ID | PUR9_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MAPGQLALFSVSDKTGLVEF ARNLTALGLNLVASGGTAKA LRDAGLAVRDVSELTGFPEM LGGRVKTLHPAVHAGILARN IPEDNADMARLDFNLIRVVA CNLYPFVKTVASPGVTVEEA VEQIDIGGVTLLRAAAKNHA RVTVVCEPEDYVVVSTEMQS SESKDTSLETRRQLALKAFT HTAQYDEAISDYFRKQYSKG VSQMPLRYGMNPHQTPAQLY TLQPKLPITVLNGAPGFIN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ATIC (NP_004035.2). |
Additional Info
| Tissue Specificity | Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas. |
| Function | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization. |
| Protein Name | Bifunctional Purine Biosynthesis Protein AticAicar Transformylase/Inosine Monophosphate CyclohydrolaseAtic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase5-Aminoimidazole-4-Carboxamide Ribonucleotide FormyltransferaseAicar FormyltransferaseAicar Transformylase - Inosine 5'-Monophosphate CyclohydrolaseImp CyclohydrolaseImp SynthaseInosinicase |
| Database Links | Reactome: R-HSA-73817Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Bifunctional Purine Biosynthesis Protein Atic antibodyAnti-Aicar Transformylase/Inosine Monophosphate Cyclohydrolase antibodyAnti-Atic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase antibodyAnti-5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase antibodyAnti-Aicar Formyltransferase antibodyAnti-Aicar Transformylase - Inosine 5'-Monophosphate Cyclohydrolase antibodyAnti-Imp Cyclohydrolase antibodyAnti-Imp Synthase antibodyAnti-Inosinicase antibodyAnti-ATIC antibodyAnti-PURH antibodyAnti-OK antibodyAnti-SW-cl.86 antibody |
Information sourced from Uniprot.org