| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATG9A (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. Use at a dilution of 1:300 to 1:2000. The optimal dilution should be determined by the end user. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
ATG9A |
| Gene ID: |
79065 |
| Uniprot ID: |
ATG9A_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Specific for ATG9A. |
| Immunogen: |
A synthetic peptide from c-terminal region of human Autophagy related protein 9A (ATG9A) conjugated to an immunogenic carrier protein has been used as the antigen. |
| Function | Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death. |
| Protein Name | Autophagy-Related Protein 9aApg9-Like 1Matg9 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-5205685 |
| Cellular Localisation | Preautophagosomal Structure MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleAutophagosome MembraneGolgi ApparatusTrans-Golgi Network MembraneLate Endosome MembraneRecycling Endosome MembraneEndoplasmic Reticulum MembraneMitochondrion MembraneMainly Localizes To The Trans-Golgi Network (Tgn) And The Endosomal SystemCycles Between Them Though Vesicle TraffickingExport From The Tgn To Promote Formation Of Autophagosomes Is Mediated By The Ap-4 ComplexUnder Amino Acid Starvation Or Rapamycin TreatmentRedistributes To Preautophagosomal Structure/Phagophore Assembly Site (Pas)The Starvation-Induced Redistribution Depends On Ulk1Atg13As Well As Sh3glb1Upon Autophagy InductionA Small Portion Transiently Localizes To The Autophagic MembranesRecruited To Damaged Mitochondria During Mitophagy In A Rimoc1-Dependent Manner |
| Alternative Antibody Names | Anti-Autophagy-Related Protein 9a antibodyAnti-Apg9-Like 1 antibodyAnti-Matg9 antibodyAnti-ATG9A antibodyAnti-APG9L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
