| Short Description : | Rabbit polyclonal ATG2A (700-800) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATG2A |
| Gene ID: | 23130 |
| Uniprot ID: | ATG2A_HUMAN |
| Immunogen Region: | 700-800 |
| Immunogen Sequence: | DLHGIYEDGGKPPVPCLRVS KALDPKSTGRKYFLPQVVVT VNPQSSSTQWEVAPEKGEEL ELSVESPCELREPEPSPFSS KRTMYETEEMVIPGDPEEMR T |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human ATG2A (NP_055919.2). |
| Function | Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Also regulates lipid droplets morphology and distribution within the cell. |
| Protein Name | Autophagy-Related Protein 2 Homolog A |
| Database Links | |
| Cellular Localisation | Preautophagosomal Structure MembranePeripheral Membrane ProteinLipid DropletEndoplasmic Reticulum MembraneLocalizes To Endoplasmic Reticulum-Autophagosome Contact Sites |
| Alternative Antibody Names | Anti-Autophagy-Related Protein 2 Homolog A antibodyAnti-ATG2A antibodyAnti-KIAA0404 antibody |
Information sourced from Uniprot.org
