| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ATG2A (700-800) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATG2A |
| Gene ID: |
23130 |
| Uniprot ID: |
ATG2A_HUMAN |
| Immunogen Region: |
700-800 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human ATG2A (NP_055919.2). |
| Immunogen Sequence: |
DLHGIYEDGGKPPVPCLRVS KALDPKSTGRKYFLPQVVVT VNPQSSSTQWEVAPEKGEEL ELSVESPCELREPEPSPFSS KRTMYETEEMVIPGDPEEMR T |
| Function | Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Also regulates lipid droplets morphology and distribution within the cell. |
| Protein Name | Autophagy-Related Protein 2 Homolog A |
| Cellular Localisation | Preautophagosomal Structure MembranePeripheral Membrane ProteinLipid DropletEndoplasmic Reticulum MembraneLocalizes To Endoplasmic Reticulum-Autophagosome Contact Sites |
| Alternative Antibody Names | Anti-Autophagy-Related Protein 2 Homolog A antibodyAnti-ATG2A antibodyAnti-KIAA0404 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
