Anti-ATF1 antibody [SRM15018] (STJ11109748)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-89 of human ATF1 (NP_005162.1).
General Information
| Short Description | Rabbit monoclonal ATF1 antibody for use in WB, IF, ICC, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM15018 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:7000-1:14000IF/ICC, 1:200-1:400IHC-P, 1:500-1:2000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATF1 |
| Gene ID | 466 |
| Uniprot ID | ATF1_HUMAN |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-89 of human ATF1 (NP_005162.1). |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-198 by HIPK2 in response to genotoxic stress. This phosphorylation promotes transcription repression of FTH1 and other antioxidant detoxification genes. The CDK3-mediated phosphorylation at Ser-63 promotes its transactivation and transcriptional activities. Phosphorylated at Ser-63 by RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. |
| Function | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGTACAG-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. |
| Protein Name | Cyclic Amp-Dependent Transcription Factor Atf-1Camp-Dependent Transcription Factor Atf-1Activating Transcription Factor 1Protein Treb36 |
| Database Links | Reactome: R-HSA-199920Reactome: R-HSA-9031628 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Dependent Transcription Factor Atf-1 antibodyAnti-Camp-Dependent Transcription Factor Atf-1 antibodyAnti-Activating Transcription Factor 1 antibodyAnti-Protein Treb36 antibodyAnti-ATF1 antibody |
Information sourced from Uniprot.org