Anti-ATAD3A antibody (433-483 aa) (STJ194979)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ATD3A at the amino acid range 433-483
General Information
| Short Description | Rabbit polyclonal anti-ATPase family AAA domain-containing protein 3A (433-483 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATAD3A |
| Gene ID | 55210 |
| Uniprot ID | ATD3A_HUMAN |
| Immunogen | Synthesized peptide derived from the human ATD3A at the amino acid range 433-483 |
| Immunogen Region | 433-483 aa |
| Specificity | This antibody detects endogenous levels of ATD3A at Human |
Additional Info
| Function | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress. Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity. Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR). |
| Protein Name | Atpase Family Aaa Domain-Containing Protein 3a |
| Database Links | |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinMitochondrion MatrixMitochondrion NucleoidIn The Mitochondrial Inner MembraneEnriched In Sites With The Potential To Form Contacts With The Outer MembraneThe N-Terminal Domain Interacts With The Inner Surface Of The Mitochondrial Outer Membrane And The C-Terminal Domain Localizes In A Specific Matrix CompartmentWhere It Is Associated With NucleoidsAlso Present At Mitochondria-Endoplasmic Reticulum Contact SitesWhere It Interacts With Eif2ak3/Perk |
| Alternative Antibody Names | Anti-Atpase Family Aaa Domain-Containing Protein 3a antibodyAnti-ATAD3A antibody |
Information sourced from Uniprot.org