Anti-AT1R/AGTR1 antibody (1-100) [S6MR] (STJ11103556)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal AT1R/AGTR1 (1-100) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S6MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AGTR1 |
| Gene ID | 185 |
| Uniprot ID | AGTR1_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MILNSSTEDGIKRIQDDCPK AGRHNYIFVMIPTLYSIIFV VGIFGNSLVVIVIYFYMKLK TVASVFLLNLALADLCFLLT LPLWAVYTAMEYRWPFGNYL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AT1R/AGTR1 (P30556). |
Additional Info
| Tissue Specificity | Liver, lung, adrenal and adrenocortical adenomas. |
| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. |
| Function | Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. |
| Protein Name | Type-1 Angiotensin Ii ReceptorAt1arAt1brAngiotensin Ii Type-1 ReceptorAt1 Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Type-1 Angiotensin Ii Receptor antibodyAnti-At1ar antibodyAnti-At1br antibodyAnti-Angiotensin Ii Type-1 Receptor antibodyAnti-At1 Receptor antibodyAnti-AGTR1 antibodyAnti-AGTR1A antibodyAnti-AGTR1B antibodyAnti-AT2R1 antibodyAnti-AT2R1B antibody |
Information sourced from Uniprot.org