Anti-ASXL3 antibody (1892-1942 aa) (STJ198090)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ASXL3 at the amino acid range 1892-1942
General Information
| Short Description | Rabbit polyclonal anti-Putative Polycomb group protein ASXL3 (1892-1942 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASXL3 |
| Gene ID | 80816 |
| Uniprot ID | ASXL3_HUMAN |
| Immunogen | Synthesized peptide derived from the human ASXL3 at the amino acid range 1892-1942 |
| Immunogen Region | 1892-1942 aa |
| Specificity | This antibody detects endogenous levels of human ASXL3 |
Additional Info
| Function | Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability. ASXL1, ASXL2 and ASXL3 function redundantly in the PR-DUB complex and are essential for chromatin recruitment and transcriptional activation of associated genes. |
| Protein Name | Putative Polycomb Group Protein Asxl3Additional Sex Combs-Like Protein 3 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Putative Polycomb Group Protein Asxl3 antibodyAnti-Additional Sex Combs-Like Protein 3 antibodyAnti-ASXL3 antibodyAnti-KIAA1713 antibody |
Information sourced from Uniprot.org