Anti-AST1/GOT1 antibody (1-413aa) [AT3G11] (STJA0041819)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
ImmunogenRecombinant human GOT1 (1-413aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-AST1/GOT1 (1-413aa) for use in ELISA, WB, ICC, IF and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF/FACS |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT3G11 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GOT1 |
| Gene ID | 2805 |
| Uniprot ID | AATC_HUMAN |
| Accession Number | NP_002070 |
| Immunogen | Recombinant human GOT1 (1-413aa) purified from E. coli |
| Immunogen Region | 1-413aa |
Additional Info
| Function | Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway. |
| Protein Name | Aspartate Aminotransferase - CytoplasmicCaspatCysteine Aminotransferase - CytoplasmicCysteine Transaminase - CytoplasmicCcatGlutamate Oxaloacetate Transaminase 1Transaminase A |
| Database Links | Reactome: R-HSA-1237112Reactome: R-HSA-8963693Reactome: R-HSA-9856872 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Aspartate Aminotransferase - Cytoplasmic antibodyAnti-Caspat antibodyAnti-Cysteine Aminotransferase - Cytoplasmic antibodyAnti-Cysteine Transaminase - Cytoplasmic antibodyAnti-Ccat antibodyAnti-Glutamate Oxaloacetate Transaminase 1 antibodyAnti-Transaminase A antibodyAnti-GOT1 antibody |
Information sourced from Uniprot.org