| Short Description : | Rabbit polyclonal ASPM (450-550) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ASPM |
| Gene ID: | 259266 |
| Uniprot ID: | ASPM_HUMAN |
| Immunogen Region: | 450-550 |
| Immunogen Sequence: | IFEELVEMKSNYYSFIKQNN PKFSAVQDISSHSHNKQPKR RPILSATVTKRKATCTRENQ TEINKPKAKRCLNSAVGEHE KVINNQKEKEDFHSYLPIID P |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human ASPM (NP_060606.3). |
| Function | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis. |
| Protein Name | Abnormal Spindle-Like Microcephaly-Associated ProteinAbnormal Spindle Protein HomologAsp Homolog |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonSpindleNucleusThe Nuclear-Cytoplasmic Distribution Could Be Regulated By The Availability Of CalmodulinLocalizes To Spindle Poles During MitosisAssociates With Microtubule Minus Ends |
| Alternative Antibody Names | Anti-Abnormal Spindle-Like Microcephaly-Associated Protein antibodyAnti-Abnormal Spindle Protein Homolog antibodyAnti-Asp Homolog antibodyAnti-ASPM antibodyAnti-MCPH5 antibody |
Information sourced from Uniprot.org
