| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ASPM |
| Gene ID: | 259266 |
| Uniprot ID: | ASPM_HUMAN |
| Immunogen Region: | 450-550 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human ASPM (NP_060606.3). |
| Immunogen Sequence: | IFEELVEMKSNYYSFIKQNN PKFSAVQDISSHSHNKQPKR RPILSATVTKRKATCTRENQ TEINKPKAKRCLNSAVGEHE KVINNQKEKEDFHSYLPIID P |
| Function | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis. |
| Protein Name | Abnormal Spindle-Like Microcephaly-Associated Protein Abnormal Spindle Protein Homolog Asp Homolog |
| Cellular Localisation | Cytoplasm Cytoskeleton Spindle Nucleus The Nuclear-Cytoplasmic Distribution Could Be Regulated By The Availability Of Calmodulin Localizes To Spindle Poles During Mitosis Associates With Microtubule Minus Ends |
| Alternative Antibody Names | Anti-Abnormal Spindle-Like Microcephaly-Associated Protein antibody Anti-Abnormal Spindle Protein Homolog antibody Anti-Asp Homolog antibody Anti-ASPM antibody Anti-MCPH5 antibody |
Information sourced from Uniprot.org