| Function | Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex. May have a preferential role in regulating neurogenesis. |
| Protein Name | Abnormal Spindle-Like Microcephaly-Associated ProteinAbnormal Spindle Protein HomologAsp Homolog |
| Cellular Localisation | CytoplasmCytoskeletonSpindleNucleusThe Nuclear-Cytoplasmic Distribution Could Be Regulated By The Availability Of CalmodulinLocalizes To Spindle Poles During MitosisAssociates With Microtubule Minus Ends |
| Alternative Antibody Names | Anti-Abnormal Spindle-Like Microcephaly-Associated Protein antibodyAnti-Abnormal Spindle Protein Homolog antibodyAnti-Asp Homolog antibodyAnti-ASPM antibodyAnti-MCPH5 antibody |
Information sourced from Uniprot.org
