Anti-ASNA1 antibody (Internal) (STJ71537)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ASNA1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 38kDa band observed in Human, Mouse and Rat Kidney lysates (calculated MW of 38.8kDa according to Human NP_004308.2). Recommended concentration: 0.3-1µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | GET3 |
| Gene ID | 439 |
| Uniprot ID | GET3_HUMAN |
| Accession Number | NP_004308.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | PHEVRGADKVNT |
Additional Info
| Function | ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. |
| Protein Name | Atpase Get3Arsenical Pump-Driving AtpaseArsenite-Stimulated AtpaseGuided Entry Of Tail-Anchored Proteins Factor 3 - AtpaseTransmembrane Domain Recognition Complex 40 Kda Atpase SubunitHarsa-IHasna-I |
| Database Links | Reactome: R-HSA-9609523 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumNucleusNucleolus |
| Alternative Antibody Names | Anti-Atpase Get3 antibodyAnti-Arsenical Pump-Driving Atpase antibodyAnti-Arsenite-Stimulated Atpase antibodyAnti-Guided Entry Of Tail-Anchored Proteins Factor 3 - Atpase antibodyAnti-Transmembrane Domain Recognition Complex 40 Kda Atpase Subunit antibodyAnti-Harsa-I antibodyAnti-Hasna-I antibodyAnti-GET3 antibodyAnti-ARSA antibodyAnti-ASNA1 antibodyAnti-TRC40 antibody |
Information sourced from Uniprot.org