Anti-ASNA1 antibody (300-348) {Biotin} (STJ500178)

SKU:
STJ500178-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ASNA1 (300-348) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.52-.53 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GET3
Gene ID: 439
Uniprot ID: GET3_HUMAN
Immunogen Region: 300-348
Immunogen: Synthetic peptide taken within amino acid region 300-348 on human ATPase ASNA1 protein.
Tissue Specificity Expressed in the epithelial cells of the liver, kidney, and stomach wall, in the adrenal medulla, in the islet cells of the pancreas, in the red pulp of the spleen, and in cardiac and skeletal muscle.
Function ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling.
Protein Name Atpase Get3
Arsenical Pump-Driving Atpase
Arsenite-Stimulated Atpase
Guided Entry Of Tail-Anchored Proteins Factor 3 - Atpase
Transmembrane Domain Recognition Complex 40 Kda Atpase Subunit
Harsa-I
Hasna-I
Database Links Reactome: R-HSA-9609523
Cellular Localisation Cytoplasm
Endoplasmic Reticulum
Nucleus
Nucleolus
Alternative Antibody Names Anti-Atpase Get3 antibody
Anti-Arsenical Pump-Driving Atpase antibody
Anti-Arsenite-Stimulated Atpase antibody
Anti-Guided Entry Of Tail-Anchored Proteins Factor 3 - Atpase antibody
Anti-Transmembrane Domain Recognition Complex 40 Kda Atpase Subunit antibody
Anti-Harsa-I antibody
Anti-Hasna-I antibody
Anti-GET3 antibody
Anti-ARSA antibody
Anti-ASNA1 antibody
Anti-TRC40 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance