Anti-ASMTL antibody (1-290) (STJ29101)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ASMTL (1-290) antibody for use in WB, IP and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASMTL |
| Gene ID | 8623 |
| Uniprot ID | ASML_HUMAN |
| Immunogen Region | 1-290 |
| Immunogen Sequence | MVLCPVIGKLLHKRVVLASA SPRRQEILSNAGLRFEVVPS KFKEKLDKASFATPYGYAME TAKQKALEVANRLYQKDLRA PDVVIGADTIVTVGGLILEK PVDKQDAYRMLSRLSGREHS VFTGVAIVHCSSKDHQLDTR VSEFYEETKVKFSELSEELL WEYVHSGEPMDKAGGYGIQA LGGMLVESVHGDFLNVVGFP LNHFCKQLVKLYYPPRPEDL RRSVKHDSIPAADTFEDLS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human ASMTL (NP_004183.2). |
Additional Info
| Tissue Specificity | Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver. |
| Function | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). |
| Protein Name | Probable Bifunctional Dttp/Utp Pyrophosphatase/Methyltransferase Protein Includes - Dttp/Utp PyrophosphataseDttpase/UtpaseNucleoside Triphosphate PyrophosphataseNucleotide PyrophosphataseNucleotide Ppase - N-Acetylserotonin O-Methyltransferase-Like ProteinAsmtl |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Probable Bifunctional Dttp/Utp Pyrophosphatase/Methyltransferase Protein Includes - Dttp/Utp Pyrophosphatase antibodyAnti-Dttpase/Utpase antibodyAnti-Nucleoside Triphosphate Pyrophosphatase antibodyAnti-Nucleotide Pyrophosphatase antibodyAnti-Nucleotide Ppase - N-Acetylserotonin O-Methyltransferase-Like Protein antibodyAnti-Asmtl antibodyAnti-ASMTL antibody |
Information sourced from Uniprot.org