| Host: |
Rabbit |
| Applications: |
WB/IP |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ASMTL (1-290) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IP 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ASMTL |
| Gene ID: |
8623 |
| Uniprot ID: |
ASML_HUMAN |
| Immunogen Region: |
1-290 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human ASMTL (NP_004183.2). |
| Immunogen Sequence: |
MVLCPVIGKLLHKRVVLASA SPRRQEILSNAGLRFEVVPS KFKEKLDKASFATPYGYAME TAKQKALEVANRLYQKDLRA PDVVIGADTIVTVGGLILEK PVDKQDAYRMLSRLSGREHS VFTGVAIVHCSSKDHQLDTR VSEFYEETKVKFSELSEELL WEYVHSGEPMDKAGGYGIQA LGGMLVESVHGDFLNVVGFP LNHFCKQLVKLYYPPRPEDL RRSVKHDSIPAADTFEDLS |
| Tissue Specificity | Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver. |
| Function | Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). |
| Protein Name | Probable Bifunctional Dttp/Utp Pyrophosphatase/Methyltransferase Protein Includes - Dttp/Utp PyrophosphataseDttpase/UtpaseNucleoside Triphosphate PyrophosphataseNucleotide PyrophosphataseNucleotide Ppase - N-Acetylserotonin O-Methyltransferase-Like ProteinAsmtl |
| Alternative Antibody Names | Anti-Probable Bifunctional Dttp/Utp Pyrophosphatase/Methyltransferase Protein Includes - Dttp/Utp Pyrophosphatase antibodyAnti-Dttpase/Utpase antibodyAnti-Nucleoside Triphosphate Pyrophosphatase antibodyAnti-Nucleotide Pyrophosphatase antibodyAnti-Nucleotide Ppase - N-Acetylserotonin O-Methyltransferase-Like Protein antibodyAnti-Asmtl antibodyAnti-ASMTL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and MSH6 knockout (KO) HeLa cells, using [KO Validated] MSH6 Rabbit polyclonal antibody (STJ119980) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/98765/382817/STJ119980_1__09948.1713151312.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and MSH6 knockout (KO) HeLa cells, using [KO Validated] MSH6 Rabbit polyclonal antibody (STJ119980) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1min.")
