Anti-ASIC2 antibody (Extracellular) (STJ13100483)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from mouse ASIC2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in human and rat.
General Information
| Short Description | Rabbit polyclonal anti-ASIC2 (Extracellular) for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Asic2 |
| Gene ID | 25364 |
| Uniprot ID | ASIC2_RAT |
| Immunogen | A synthetic peptide from mouse ASIC2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in human and rat. |
| Immunogen Region | Extracellular |
| Specificity | Specific for ASIC2. |
Additional Info
| Function | Forms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system. Upon extracellular acidification, these channels generate rapid, transient inward currents that fully desensitize. Highly selective for sodium, they are permeable to other cations. By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory. Additionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction. Isoform 2: Has no pH-gated sodium channel activity per se but can associate with other ASICs to produce functional channels with specific properties. |
| Protein Name | Acid-Sensing Ion Channel 2Asic2Amiloride-Sensitive Brain Sodium ChannelAmiloride-Sensitive Brain Sodium Channel 2Amiloride-Sensitive Cation Channel 1 - NeuronalAmiloride-Sensitive Cation Channel Neuronal 1Brain Sodium Channel 1Bnc1Bnac1Mammalian Degenerin HomologMdeg |
| Database Links | Reactome: R-RNO-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized At The Plasma Membrane Of NeuronsIn The Soma And Punctated Peripheral Processes |
| Alternative Antibody Names | Anti-Acid-Sensing Ion Channel 2 antibodyAnti-Asic2 antibodyAnti-Amiloride-Sensitive Brain Sodium Channel antibodyAnti-Amiloride-Sensitive Brain Sodium Channel 2 antibodyAnti-Amiloride-Sensitive Cation Channel 1 - Neuronal antibodyAnti-Amiloride-Sensitive Cation Channel Neuronal 1 antibodyAnti-Brain Sodium Channel 1 antibodyAnti-Bnc1 antibodyAnti-Bnac1 antibodyAnti-Mammalian Degenerin Homolog antibodyAnti-Mdeg antibodyAnti-Asic2 antibodyAnti-Accn1 antibodyAnti-Bnac1 antibody |
Information sourced from Uniprot.org