Anti-ASGR1 antibody (1-150) (STJ28951)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ASGR1 (1-150) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASGR1 |
| Gene ID | 432 |
| Uniprot ID | ASGR1_HUMAN |
| Immunogen Region | 1-150 |
| Immunogen Sequence | MTKEYQDLQHLDNEESDHHQ LRKGPPPPQPLLQRLCSGPR LLLLSLGLSLLLLVVVCVIG SQNSQLQEELRGLRETFSNF TASTEAQVKGLSTQGGNVGR KMKSLESQLEKQQKDLSEDH SSLLLHVKQFVSDLRSLSCQ MAALQGNGSE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ASGR1 (NP_001662.1). |
Additional Info
| Tissue Specificity | Expressed exclusively in hepatic parenchymal cells. |
| Post Translational Modifications | Phosphorylated on a cytoplasmic Ser residue. |
| Function | Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. |
| Protein Name | Asialoglycoprotein Receptor 1Asgp-R 1Asgpr 1C-Type Lectin Domain Family 4 Member H1Hepatic Lectin H1Hl-1 |
| Database Links | Reactome: R-HSA-446203 |
| Cellular Localisation | Isoform H1a: MembraneSingle-Pass Type Ii Membrane ProteinIsoform H1b: Secreted |
| Alternative Antibody Names | Anti-Asialoglycoprotein Receptor 1 antibodyAnti-Asgp-R 1 antibodyAnti-Asgpr 1 antibodyAnti-C-Type Lectin Domain Family 4 Member H1 antibodyAnti-Hepatic Lectin H1 antibodyAnti-Hl-1 antibodyAnti-ASGR1 antibodyAnti-CLEC4H1 antibody |
Information sourced from Uniprot.org