Anti-ASF1B antibody (63-202) (STJ28594)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ASF1B (63-202) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASF1B |
| Gene ID | 55723 |
| Uniprot ID | ASF1B_HUMAN |
| Immunogen Region | 63-202 |
| Immunogen Sequence | GPVPAGRHMFVFQADAPNPS LIPETDAVGVTVVLITCTYH GQEFIRVGYYVNNEYLNPEL RENPPMKPDFSQLQRNILAS NPRVTRFHINWDNNMDRLEA IETQDPSLGCGLPLNCTPIK GLGLPGCIPGLLPENSMDCI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 63-202 of human ASF1B (NP_060624.1). |
Additional Info
| Tissue Specificity | Highly expressed in testis and at lower levels in colon, small intestine and thymus. |
| Post Translational Modifications | Phosphorylated by TLK1 and TLK2. |
| Function | Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for gonad development. |
| Protein Name | Histone Chaperone Asf1bAnti-Silencing Function Protein 1 Homolog BHasf1Hasf1bCcg1-Interacting Factor A-IiCia-IiHcia-Ii |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Histone Chaperone Asf1b antibodyAnti-Anti-Silencing Function Protein 1 Homolog B antibodyAnti-Hasf1 antibodyAnti-Hasf1b antibodyAnti-Ccg1-Interacting Factor A-Ii antibodyAnti-Cia-Ii antibodyAnti-Hcia-Ii antibodyAnti-ASF1B antibody |
Information sourced from Uniprot.org