| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AscL1 (150-236) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ASCL1 |
| Gene ID: |
429 |
| Uniprot ID: |
ASCL1_HUMAN |
| Immunogen Region: |
150-236 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 150-236 of human AscL1 (NP_004307.2). |
| Immunogen Sequence: |
ANKKMSKVETLRSAVEYIRA LQQLLDEHDAVSAAFQAGVL SPTISPNYSNDLNSMAGSPV SSYSSDEGSYDPLSPEEQEL LDFTNWF |
| Function | Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach. |
| Protein Name | Achaete-Scute Homolog 1Ash-1Hash1Class A Basic Helix-Loop-Helix Protein 46Bhlha46 |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Achaete-Scute Homolog 1 antibodyAnti-Ash-1 antibodyAnti-Hash1 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 46 antibodyAnti-Bhlha46 antibodyAnti-ASCL1 antibodyAnti-ASH1 antibodyAnti-BHLHA46 antibodyAnti-HASH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
