Anti-ASCC2 antibody [100000000] (STJA0032735)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFull length human recombinant protein of human ASCC2 produced in 293T cell.
General Information
| Short Description | Mouse monoclonal anti-ASCC2 for use in WB and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 100000000 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.47 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000FC 1:50-1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ASCC2 |
| Gene ID | 84164 |
| Uniprot ID | ASCC2_HUMAN |
| Immunogen | Full length human recombinant protein of human ASCC2 produced in 293T cell. |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes. Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes. |
| Protein Name | Activating Signal Cointegrator 1 Complex Subunit 2Asc-1 Complex Subunit P100Trip4 Complex Subunit P100 |
| Database Links | Reactome: R-HSA-112126 |
| Cellular Localisation | NucleusNucleus SpeckleColocalizes With The Spliceosomal Components Prpf8 And Snrnp200/Brr2 In Nuclear Foci When Cells Have Been Exposed To Alkylating Agents That Cause Dna DamageColocalizes With Rnf113a And 'Lys-63'-Linked Polyubiquitinated ProteinsAlkbh3 And Ascc3 In Nuclear Foci When Cells Have Been Exposed To Alkylating Agents That Cause Dna Damage |
| Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 Complex Subunit 2 antibodyAnti-Asc-1 Complex Subunit P100 antibodyAnti-Trip4 Complex Subunit P100 antibodyAnti-ASCC2 antibodyAnti-ASC1P100 antibodyAnti-RQT3 antibody |
Information sourced from Uniprot.org