Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ASCC1 |
Gene ID: | 51008 |
Uniprot ID: | ASCC1_HUMAN |
Immunogen Region: | 1-180 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ASCC1 (NP_001185727.1). |
Immunogen Sequence: | MEVLRPQLIRIDGRNYRKNP VQEQTYQHEEDEEDFYQGSM ECADEPCDAYEVEQTPQGFR STLRAPSLLYKHIVGKRGDT RKKIEMETKTSISIPKPGQD GEIVITGQHRNGVISARTRI DVLLDTFRRKQPFTHFLAFF LNEVEVQEGFLRFQEEVLAK CSMDHGVDSSIFQNPKKLHL |
Tissue Specificity | Ubiquitous. |
Function | Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction. |
Protein Name | Activating Signal Cointegrator 1 Complex Subunit 1Asc-1 Complex Subunit P50Trip4 Complex Subunit P50 |
Database Links | Reactome: R-HSA-112126 |
Cellular Localisation | NucleusNucleus SpeckleColocalizes With Prpf8 In Nuclear Speckles In The Absence Of Dna Damage |
Alternative Antibody Names | Anti-Activating Signal Cointegrator 1 Complex Subunit 1 antibodyAnti-Asc-1 Complex Subunit P50 antibodyAnti-Trip4 Complex Subunit P50 antibodyAnti-ASCC1 antibodyAnti-CGI-18 antibody |
Information sourced from Uniprot.org