Anti-ASCC1 antibody (1-180) (STJ118277)

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STJ118277
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ASCC1
Gene ID: 51008
Uniprot ID: ASCC1_HUMAN
Immunogen Region: 1-180
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ASCC1 (NP_001185727.1).
Immunogen Sequence: MEVLRPQLIRIDGRNYRKNP VQEQTYQHEEDEEDFYQGSM ECADEPCDAYEVEQTPQGFR STLRAPSLLYKHIVGKRGDT RKKIEMETKTSISIPKPGQD GEIVITGQHRNGVISARTRI DVLLDTFRRKQPFTHFLAFF LNEVEVQEGFLRFQEEVLAK CSMDHGVDSSIFQNPKKLHL
Tissue Specificity Ubiquitous.
Function Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.
Protein Name Activating Signal Cointegrator 1 Complex Subunit 1
Asc-1 Complex Subunit P50
Trip4 Complex Subunit P50
Database Links Reactome: R-HSA-112126
Cellular Localisation Nucleus
Nucleus Speckle
Colocalizes With Prpf8 In Nuclear Speckles In The Absence Of Dna Damage
Alternative Antibody Names Anti-Activating Signal Cointegrator 1 Complex Subunit 1 antibody
Anti-Asc-1 Complex Subunit P50 antibody
Anti-Trip4 Complex Subunit P50 antibody
Anti-ASCC1 antibody
Anti-CGI-18 antibody

Information sourced from Uniprot.org