Anti-ASB8 antibody (STJA0008851)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ASB8
General Information
| Short Description | Rabbit polyclonal anti-Ankyrin repeat and SOCS box protein 8 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASB8 |
| Gene ID | 140461 |
| Uniprot ID | ASB8_HUMAN |
| Immunogen | Synthesized peptide derived from human ASB8 |
| Specificity | This antibody detects endogenous levels of ASB8 at Human, Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated by TBK1. |
| Function | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation. |
| Protein Name | Ankyrin Repeat And Socs Box Protein 8Asb-8 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Socs Box Protein 8 antibodyAnti-Asb-8 antibodyAnti-ASB8 antibodyAnti-PP14212 antibody |
Information sourced from Uniprot.org