Anti-ASB8 antibody (STJA0004775)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human ASB8
General Information
| Short Description | Rabbit polyclonal anti-Ankyrin Repeat And Socs Box Protein 8 for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.7 mg/mL |
| Purification | Affinity purification |
| Dilution Range | IHC 1:25-1:100 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ASB8 |
| Gene ID | 140461 |
| Uniprot ID | ASB8_HUMAN |
| Immunogen | Recombinant protein of human ASB8 |
Additional Info
| Tissue Specificity | Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas. |
| Post Translational Modifications | Phosphorylated by TBK1. |
| Function | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation. |
| Protein Name | Ankyrin Repeat And Socs Box Protein 8Asb-8 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Socs Box Protein 8 antibodyAnti-Asb-8 antibodyAnti-ASB8 antibodyAnti-PP14212 antibody |
Information sourced from Uniprot.org