| Tissue Specificity | Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas. |
| Post Translational Modifications | Phosphorylated by TBK1. |
| Function | May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation. |
| Protein Name | Ankyrin Repeat And Socs Box Protein 8Asb-8 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Socs Box Protein 8 antibodyAnti-Asb-8 antibodyAnti-ASB8 antibodyAnti-PP14212 antibody |
Information sourced from Uniprot.org
