Anti-ASB3 antibody (1-145 aa) (STJ11106526)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ASB3 (1-145 aa) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ASB3 |
| Gene ID | 100302652/51130 |
| Uniprot ID | ASB3_HUMAN |
| Immunogen Region | 1-145 aa |
| Immunogen Sequence | MDFTEAYADTCSTVGLAARE GNVKVLRKLLKKGRSVDVAD NRGWMPIHEAAYHNSVECLQ MLINADSSENYIKMKTFEGF CALHLAASQGHWKIVQILLE AGADPNATTLEETTPLFLAV ENGQIDVLRLLLQHGANVNG SHSMC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human ASB3 (NP_057199.1). |
Additional Info
| Function | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. Plays a role in the down-regulation of antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation. Also destabilizes TRAF6 by enhancing its 'Lys-48'-linked polyubiquitination. |
| Protein Name | Ankyrin Repeat And Socs Box Protein 3Asb-3 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ankyrin Repeat And Socs Box Protein 3 antibodyAnti-Asb-3 antibodyAnti-ASB3 antibody |
Information sourced from Uniprot.org