| Tissue Specificity | Primarily expressed in intestine. Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart. The ubiquitous expression observed for ASAH2 might be an experimental artifact due to the paralog ASAH2B. |
| Post Translational Modifications | Proteolytic cleavage of the N-terminus removes the signal-anchor and produces a soluble form of the protein. N-glycosylated. Required for enzyme activity. O-glycosylated. Required to retain it as a type II membrane protein at the cell surface. Phosphorylated. May prevent ubiquitination and subsequent degradation. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by nitric oxide. |
| Function | Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells. Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells. This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract. |
| Protein Name | Neutral CeramidaseN-CdaseNcdaseAcylsphingosine Deacylase 2BcdaseLcdaseHcdN-Acylsphingosine Amidohydrolase 2Non-Lysosomal Ceramidase Cleaved Into - Neutral Ceramidase Soluble Form |
| Database Links | Reactome: R-HSA-9840310 |
| Cellular Localisation | Neutral Ceramidase: Cell MembraneSingle-Pass Type Ii Membrane ProteinMembrane RaftMembraneCaveolaGolgi Apparatus MembraneMitochondrionSecretedExtracellular ExosomeEnriched In Exosomes Upon Stimulation By CytokineEnriched In Caveolae And Lipid RaftsThe Localization To The Mitochondrion Could Not Be ConfirmedNeutral Ceramidase Soluble Form: Secreted |
| Alternative Antibody Names | Anti-Neutral Ceramidase antibodyAnti-N-Cdase antibodyAnti-Ncdase antibodyAnti-Acylsphingosine Deacylase 2 antibodyAnti-Bcdase antibodyAnti-Lcdase antibodyAnti-Hcd antibodyAnti-N-Acylsphingosine Amidohydrolase 2 antibodyAnti-Non-Lysosomal Ceramidase Cleaved Into - Neutral Ceramidase Soluble Form antibodyAnti-ASAH2 antibodyAnti-HNAC1 antibody |
Information sourced from Uniprot.org
