| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-HIF1 Beta/ARNT (499-789) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S1MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ARNT |
| Gene ID: |
405 |
| Uniprot ID: |
ARNT_HUMAN |
| Immunogen Region: |
499-789 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 499-789 of human HIF-1 beta (P27540). |
| Immunogen Sequence: |
LAPRQQQQQTELDMVPGRDG LASYNHSQVVQPVTTTGPEH SKPLEKSDGLFAQDRDPRFS EIYHNINADQSKGISSSTVP ATQQLFSQGNTFPPTPRPAE NFRNSGLAPPVTIVQPSASA GQMLAQISRHSNPTQGATPT WTPTTRSGFSAQQVATQATA KTRTSQFGVGSFQTPSSFSS MSLPGAPTASPGAAAYPSLT NRGSNFAPETGQTAGQFQTR TAEGVGVWPQWQGQQPHHR |
| Function | Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (Probable). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription. |
| Protein Name | Aryl Hydrocarbon Receptor Nuclear TranslocatorArnt ProteinClass E Basic Helix-Loop-Helix Protein 2Bhlhe2Dioxin Receptor - Nuclear TranslocatorHypoxia-Inducible Factor 1-BetaHif-1-BetaHif1-Beta |
| Database Links | Reactome: R-HSA-1234158Reactome: R-HSA-1989781Reactome: R-HSA-211945Reactome: R-HSA-211976Reactome: R-HSA-211981Reactome: R-HSA-8937144Reactome: R-HSA-9768919 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Aryl Hydrocarbon Receptor Nuclear Translocator antibodyAnti-Arnt Protein antibodyAnti-Class E Basic Helix-Loop-Helix Protein 2 antibodyAnti-Bhlhe2 antibodyAnti-Dioxin Receptor - Nuclear Translocator antibodyAnti-Hypoxia-Inducible Factor 1-Beta antibodyAnti-Hif-1-Beta antibodyAnti-Hif1-Beta antibodyAnti-ARNT antibodyAnti-BHLHE2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
