Anti-Arl6/BBS3-Mouse antibody (Internal) (STJ72456)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Arl6/BBS3-Mouse (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Mouse/Rat/Cow/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary experiments gave an approx 33kDa band in Mouse Brain lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Accession Number | NP_062639.3 |
| Immunogen Region | Internal |
| Immunogen Sequence | KPSNAQSQDIVPT |
| Specificity | Reported variants represent identical protein: NP_816931.1, NP_115522.1 |
Additional Info
| Function | Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 6 |
| Database Links | Reactome: R-MMU-5620922 |
| Cellular Localisation | Cell ProjectionCilium MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCilium AxonemeCilium Basal BodyAppears In A Pattern Of Punctae Flanking The Microtubule Axoneme That Likely Correspond To Small Membrane-Associated PatchesLocalizes To The So-Called Ciliary Gate Where Vesicles Carrying Ciliary Cargo Fuse With The Membrane |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 6 antibodyAnti-Arl6 antibodyAnti-Bbs3 antibody |
Information sourced from Uniprot.org