Anti-Arl13b antibody [N295B/66] (STJA0021090)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Arl13b antibody for use in IHC and WB in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Mouse |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | N295B/66 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | Arl13b |
| Gene ID | 68146 |
| Uniprot ID | AR13B_MOUSE |
Additional Info
| Post Translational Modifications | Sumoylation is required for PKD2 entry into cilium. |
| Function | Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it.the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis. May regulate ARF6- and RAB22A-dependent endocytic recycling traffic. |
| Protein Name | Adp-Ribosylation Factor-Like Protein 13bAdp-Ribosylation Factor-Like Protein 2-Like 1Arl2-Like Protein 1Protein Hennin |
| Database Links | Reactome: R-MMU-5624958Reactome: -MMU-9013406Reactome: -MMU-9646399 |
| Cellular Localisation | Cell ProjectionCilium MembraneLipid-AnchorCiliumAssociates With The Cilium Membrane Via PalmitoylationLocalizes To Proximal Ciliary MembranesTo An Inversin-Like Subciliary Membrane CompartmentExcluding The Transition Zone |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Like Protein 13b antibodyAnti-Adp-Ribosylation Factor-Like Protein 2-Like 1 antibodyAnti-Arl2-Like Protein 1 antibodyAnti-Protein Hennin antibodyAnti-Arl13b antibodyAnti-Arl2l1 antibody |
Information sourced from Uniprot.org