| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IF |
| Reactivity: |
Human/Mouse/Rat/Dog/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-ARIH2/TRIAD1 (C-Term) is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlELISA-antibody detection limit dilution 1:8000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
ARIH2 |
| Gene ID: |
10425 |
| Uniprot ID: |
ARI2_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_006312.1 |
| Immunogen Sequence: |
EQRRRTLLKDFHDT |
| Post Translational Modifications | Ubiquitinated. Ubiquitination promotes proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets. The initial ubiquitin is then elongated. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis. |
| Protein Name | E3 Ubiquitin-Protein Ligase Arih2Ari-2Protein Ariadne-2 HomologRing-Type E3 Ubiquitin Transferase Arih2Triad1 Protein |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Arih2 antibodyAnti-Ari-2 antibodyAnti-Protein Ariadne-2 Homolog antibodyAnti-Ring-Type E3 Ubiquitin Transferase Arih2 antibodyAnti-Triad1 Protein antibodyAnti-ARIH2 antibodyAnti-ARI2 antibodyAnti-TRIAD1 antibodyAnti-HT005 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
