Anti-ARHGEF4 antibody [ARHGEF-08] (STJ16103113)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant fragment of human ARHGEF4 (amino acids 143-271)
General Information
| Short Description | Mouse monoclonal anti-ARHGEF4 for use in FC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ARHGEF-08 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | ARHGEF4 |
| Gene ID | 50649 |
| Uniprot ID | ARHG4_HUMAN |
| Immunogen | Recombinant fragment of human ARHGEF4 (amino acids 143-271) |
Additional Info
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 4Apc-Stimulated Guanine Nucleotide Exchange Factor 1AsefAsef1 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Isoform 3: CytoplasmCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SideAssociated With Membrane Ruffles |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 4 antibodyAnti-Apc-Stimulated Guanine Nucleotide Exchange Factor 1 antibodyAnti-Asef antibodyAnti-Asef1 antibodyAnti-ARHGEF4 antibodyAnti-KIAA1112 antibody |
Information sourced from Uniprot.org