Anti-ARHGEF25 antibody (STJA0006875)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human GEFT
General Information
| Short Description | Rabbit polyclonal anti-Rho guanine nucleotide exchange factor 25 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARHGEF25 |
| Gene ID | 115557 |
| Uniprot ID | ARHGP_HUMAN |
| Immunogen | Synthesized peptide derived from human GEFT |
| Specificity | This antibody detects endogenous levels of GEFT at Human, Mouse, Rat |
Additional Info
| Function | May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 25Guanine Nucleotide Exchange Factor GeftRac/Cdc42/Rho Exchange Factor GeftRhoa/Rac/Cdc42 Guanine Nucleotide Exchange Factor GeftP63rhogef |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Cell MembraneCytoplasmMyofibrilSarcomereHighly Colocalizes With Actin Regions |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 25 antibodyAnti-Guanine Nucleotide Exchange Factor Geft antibodyAnti-Rac/Cdc42/Rho Exchange Factor Geft antibodyAnti-Rhoa/Rac/Cdc42 Guanine Nucleotide Exchange Factor Geft antibodyAnti-P63rhogef antibodyAnti-ARHGEF25 antibodyAnti-GEFT antibody |
Information sourced from Uniprot.org