Anti-ARHGEF15 antibody (560-640 aa) (STJ191326)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 560-640
General Information
| Short Description | Rabbit polyclonal anti-Rho guanine nucleotide exchange factor 15 (560-640 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ARHGEF15 |
| Gene ID | 22899 |
| Uniprot ID | ARHGF_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 560-640 |
| Immunogen Region | 560-640 aa |
| Specificity | ARHGF Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination. Ubiquitinated.UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation. |
| Function | Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 15Ephexin-5E5Vsm-Rhogef |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Cell ProjectionDendriteExpressed Exclusively In Dendrites Of The Developing Hippocampus |
| Alternative Antibody Names | Anti-Rho Guanine Nucleotide Exchange Factor 15 antibodyAnti-Ephexin-5 antibodyAnti-E5 antibodyAnti-Vsm-Rhogef antibodyAnti-ARHGEF15 antibodyAnti-KIAA0915 antibody |
Information sourced from Uniprot.org