• Western blot analysis of various lysates using ARHGAP11B Rabbit polyclonal antibody (STJ119014) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 2s.

Anti-ARHGAP11B antibody (218-267) (STJ119014)

SKU:
STJ119014

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ARHGAP11B (218-267) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARHGAP11B
Gene ID: 89839
Uniprot ID: RHGBB_HUMAN
Immunogen Region: 218-267
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 218-267 of human ARHGAP11B (NP_001034930.1).
Immunogen Sequence: EKKGVYQTLSWKRYQPCWVL MVSVLLHHWKALKKVNMKLL VNIREREDNV
Function Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.
Protein Name Inactive Rho Gtpase-Activating Protein 11b
Rho-Type Gtpase-Activating Protein 11b
Database Links Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Cellular Localisation Mitochondrion Matrix
Alternative Antibody Names Anti-Inactive Rho Gtpase-Activating Protein 11b antibody
Anti-Rho-Type Gtpase-Activating Protein 11b antibody
Anti-ARHGAP11B antibody
Anti-FAM7B1 antibody

Information sourced from Uniprot.org

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