| Tissue Specificity | Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. |
| Post Translational Modifications | Phosphorylated by PTK6 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation.the interaction is mediated by the SH2 domain of PTK6. Phosphorylation promotes association with the Golgi apparatus and endosomes. |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding. Has a preference for ARF1 and ARF5. Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis. Acts as a bridging factor in osteoclasts to control actin and membrane dynamics. Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity. Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption. Regulates the endocytic trafficking of EGFR. Regulates the incorporation of CD63 and CD9 into multivesicular bodies. Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis. |
| Protein Name | Arf-Gap With Rho-Gap Domain - Ank Repeat And Ph Domain-Containing Protein 1Centaurin-Delta-2Cnt-D2 |
| Database Links | Reactome: R-HSA-8849469Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmGolgi ApparatusTrans-Golgi NetworkGolgi StackCell MembranePeripheral Membrane ProteinEndosomeMultivesicular BodyCell ProjectionRufflePodosomeEarly EndosomeAssociated With Golgi Stacks In Resting CellsThroughout The Cytoplasm And In Surface Protrusions In Cells That Are In The Process Of Attaching To A Surface And SpreadingLocalizes To Actin-Rich PodosomesSealing Zones And Early Endosomes In Osteoclasts |
| Alternative Antibody Names | Anti-Arf-Gap With Rho-Gap Domain - Ank Repeat And Ph Domain-Containing Protein 1 antibodyAnti-Centaurin-Delta-2 antibodyAnti-Cnt-D2 antibodyAnti-ARAP1 antibodyAnti-CENTD2 antibodyAnti-KIAA0782 antibody |
Information sourced from Uniprot.org
