Anti-Aquaporin 5 antibody [R05-6A3] (STJA0035983)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human AQP5
General Information
| Short Description | Rabbit monoclonal anti-Aquaporin 5 for use in WB, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-6A3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | AQP5 |
| Gene ID | 362 |
| Uniprot ID | AQP5_HUMAN |
| Immunogen | A synthesized peptide derived from human AQP5 |
Additional Info
| Tissue Specificity | Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level). |
| Function | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands. |
| Protein Name | Aquaporin-5Aqp-5 |
| Database Links | Reactome: R-HSA-432047 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneHypotonicity Increases Location At The Cell MembranePhosphorylation Decreases Location At The Cell Membrane |
| Alternative Antibody Names | Anti-Aquaporin-5 antibodyAnti-Aqp-5 antibodyAnti-AQP5 antibody |
Information sourced from Uniprot.org