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Anti-Aquaporin 4 antibody [SM5101] (STJA0005101)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein corresponding to Mouse Aquaporin 4
General Information
| Short Description | Mouse monoclonal anti-Aquaporin 4 for use in IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5101 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC/IF (H, M, R) 1:1000-1:2000/1:1000-1:2000 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Aqp4 |
| Gene ID | 11829 |
| Uniprot ID | AQP4_MOUSE |
| Immunogen | Recombinant protein corresponding to Mouse Aquaporin 4 |
Additional Info
| Post Translational Modifications | Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40%.this increase is not due to increased presence at the cell membrane. Isoform 2: Palmitoylated on its N-terminal region. Isoform 1: Not palmitoylated. |
| Function | Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability. |
| Protein Name | Aquaporin-4Aqp-4Mercurial-Insensitive Water ChannelMiwcWch4 |
| Database Links | Reactome: R-MMU-432040Reactome: -MMU-432047 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneEndosome MembraneSarcolemmaCell ProjectionActivation Of The Vasopressin Receptor Avpr1a Triggers Aqp4 Phosphorylation At Ser-180 And Promotes Its Internalization From The Cell MembraneDetected On Brain Astrocyte Processes And Astrocyte Endfeet Close To Capillaries |
| Alternative Antibody Names | Anti-Aquaporin-4 antibodyAnti-Aqp-4 antibodyAnti-Mercurial-Insensitive Water Channel antibodyAnti-Miwc antibodyAnti-Wch4 antibodyAnti-Aqp4 antibody |
Information sourced from Uniprot.org