Anti-AQP7 antibody (150-200) {FITC} (STJ500143)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationFITC
IsotypeIgG
ImmunogenSynthetic amidated peptide taken within amino acid region 150-200 on rat Aquaporin 7 protein, covalently modified and conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal antibody anti-AQP7 (150-200) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Bovine/Human/Mouse/Rat/Sheep |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | FITC |
| Concentration | 0.55-0.58 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500ELISA: 1:10, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Aqp7 |
| Gene ID | 11832 |
| Uniprot ID | AQP7_MOUSE |
| Immunogen | Synthetic amidated peptide taken within amino acid region 150-200 on rat Aquaporin 7 protein, covalently modified and conjugated to KLH. |
| Immunogen Region | 150-200 |
Additional Info
| Tissue Specificity | Detected in proximal tubules in kidney. Detected in the capillary network between muscle fibers in skeletal muscle and heart, and in spermatids and on spermatozoa tails in testis and epididymis. Detected in white and brown adipose tissue, especially on small blood vessels (at protein level). Detected in kidney and white adipose tissue. |
| Post Translational Modifications | Phosphorylation by PKA could prevent the interaction with PLIN1. |
| Function | Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels. |
| Protein Name | Aquaporin-7Aqp-7Aquaglyceroporin-7 |
| Database Links | Reactome: R-MMU-432030Reactome: -MMU-432047 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneLipid DropletInternalized From The Cell Membrane In Response To Catecholamine-Induced Activation Of PkaDetected On Intracellular Membranes And Colocalizes With Lipid DropletsColocalizes With Plin1 In AdipocytesProbably On Lipid Droplets |
| Alternative Antibody Names | Anti-Aquaporin-7 antibodyAnti-Aqp-7 antibodyAnti-Aquaglyceroporin-7 antibodyAnti-Aqp7 antibody |
Information sourced from Uniprot.org