Anti-AQP4 antibody (300-323) {Biotin} (STJ500133)

SKU:
STJ500133-100

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Host: Rabbit
Applications: ELISA/ICC/IF/IHC/IP/WB
Reactivity: Bovine/Human/Mouse/Rat/Sheep
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AQP4 (300-323) is suitable for use in ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.50-0.62 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100
ICC: 1:100
IF: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: AQP4
Gene ID: 361
Uniprot ID: AQP4_HUMAN
Immunogen Region: 300-323
Immunogen: Synthetic peptide taken within amino acid region 300-323 on rat Aquaporin 4 protein.
Tissue Specificity Detected in skeletal muscle. Detected in stomach, along the glandular base region of the fundic gland (at protein level). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary.
Post Translational Modifications Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40%. Isoform 2: Palmitoylated on its N-terminal region. Isoform 1: Not palmitoylated.
Function Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability.
Protein Name Aquaporin-4
Aqp-4
Mercurial-Insensitive Water Channel
Miwc
Wch4
Database Links Reactome: R-HSA-432040
Reactome: R-HSA-432047
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Endosome Membrane
Sarcolemma
Cell Projection
Activation Of The Vasopressin Receptor Avpr1a Triggers Aqp4 Phosphorylation At Ser-180 And Promotes Its Internalization From The Cell Membrane
Detected On Brain Astrocyte Processes And Astrocyte Endfeet Close To Capillaries
Alternative Antibody Names Anti-Aquaporin-4 antibody
Anti-Aqp-4 antibody
Anti-Mercurial-Insensitive Water Channel antibody
Anti-Miwc antibody
Anti-Wch4 antibody
Anti-AQP4 antibody

Information sourced from Uniprot.org

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