• Western blot analysis of 293 using APP-BP2 antibody.. Secondary antibody was diluted at 1:20000

Anti-APPBP2 antibody (390-470 aa) (STJ97627)

SKU:
STJ97627

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Amyloid protein-binding protein 2 (390-470 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: APPBP2
Gene ID: 10513
Uniprot ID: APBP2_HUMAN
Immunogen Region: 390-470 aa
Specificity: APP-BP2 Polyclonal Antibody detects endogenous levels of APP-BP2 protein.
Immunogen: Synthesized peptide derived from APP-BP2 at the amino acid range 390-470
Function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface.
Protein Name Amyloid Protein-Binding Protein 2
Amyloid Beta Precursor Protein-Binding Protein 2
App-Bp2
Protein Interacting With App Tail 1
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Membrane
Peripheral Membrane Protein
Associated With Membranes And Microtubules
Alternative Antibody Names Anti-Amyloid Protein-Binding Protein 2 antibody
Anti-Amyloid Beta Precursor Protein-Binding Protein 2 antibody
Anti-App-Bp2 antibody
Anti-Protein Interacting With App Tail 1 antibody
Anti-APPBP2 antibody
Anti-KIAA0228 antibody
Anti-PAT1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance