Anti-APPBP2 antibody (386-585) (STJ118226)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal APPBP2 (386-585) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APPBP2 |
| Gene ID | 10513 |
| Uniprot ID | APBP2_HUMAN |
| Immunogen Region | 386-585 |
| Immunogen Sequence | LEEIAIDCHNKETEQRLLQE AHDLHLSSLQLAKKAFGEFN VQTAKHYGNLGRLYQSMRKF KEAEEMHIKAIQIKEQLLGQ EDYEVALSVGHLASLYNYDM NQYENAEKLYLRSIAIGKKL FGEGYSGLEYDYRGLIKLYN SIGNYEKVFEYHNVLSNWNR LRDRQYSVTDALEDVSTSPQ STEEVVQSFLISQNVEGPSC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 386-585 of human APPBP2 (NP_006371.2). |
Additional Info
| Post Translational Modifications | Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP. |
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface. |
| Protein Name | Amyloid Protein-Binding Protein 2Amyloid Beta Precursor Protein-Binding Protein 2App-Bp2Protein Interacting With App Tail 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMembranePeripheral Membrane ProteinAssociated With Membranes And Microtubules |
| Alternative Antibody Names | Anti-Amyloid Protein-Binding Protein 2 antibodyAnti-Amyloid Beta Precursor Protein-Binding Protein 2 antibodyAnti-App-Bp2 antibodyAnti-Protein Interacting With App Tail 1 antibodyAnti-APPBP2 antibodyAnti-KIAA0228 antibodyAnti-PAT1 antibody |
Information sourced from Uniprot.org