Anti-APOC1 antibody (1-83) (STJ27596)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal APOC1 (1-83) antibody for use in IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APOC1 |
| Gene ID | 341 |
| Uniprot ID | APOC1_HUMAN |
| Immunogen Region | 1-83 |
| Immunogen Sequence | MRLFLSLPVLVVVLSIVLEG PAPAQGTPDVSSALDKLKEF GNTLEDKARELISRIKQSEL SAKMREWFSETFQKVKEKLK IDS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-83 of human APOC1 (NP_001636.1). |
Additional Info
| Tissue Specificity | Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen. |
| Function | Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. |
| Protein Name | Apolipoprotein C-IApo-CiApoc-IApolipoprotein C1 Cleaved Into - Truncated Apolipoprotein C-I |
| Database Links | Reactome: R-HSA-8866423Reactome: R-HSA-8964046Reactome: R-HSA-9029569 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Apolipoprotein C-I antibodyAnti-Apo-Ci antibodyAnti-Apoc-I antibodyAnti-Apolipoprotein C1 Cleaved Into - Truncated Apolipoprotein C-I antibodyAnti-APOC1 antibody |
Information sourced from Uniprot.org