Anti-APOBEC3D/F antibody (232-281 aa) (STJ91636)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human APOBEC3D/F at the amino acid range 232-281
General Information
| Short Description | Rabbit polyclonal anti-DNA dC->dU-editing enzyme APOBEC-3D and DNA dC->dU-editing enzyme APOBEC-3F (232-281 aa) for use in WB, IHC, IF and ELISA in Human and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APOBEC3DAPOBEC3F |
| Gene ID | 140564200316 |
| Uniprot ID | ABC3D_HUMANABC3F_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human APOBEC3D/F at the amino acid range 232-281 |
| Immunogen Region | 232-281 aa |
| Specificity | APOBEC3D/F Polyclonal Antibody detects endogenous levels of APOBEC3D/F protein. |
Additional Info
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. |
| Protein Name | Dna Dc->Du-Editing Enzyme Apobec-3fApolipoprotein B Mrna-Editing Enzyme Catalytic Polypeptide-Like 3fA3f |
| Cellular Localisation | CytoplasmP-Body |
| Alternative Antibody Names | Anti-Dna Dc->Du-Editing Enzyme Apobec-3f antibodyAnti-Apolipoprotein B Mrna-Editing Enzyme Catalytic Polypeptide-Like 3f antibodyAnti-A3f antibodyAnti-APOBEC3F antibody |
Information sourced from Uniprot.org