Anti-APOBEC3D antibody (207-386) (STJ113251)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal APOBEC3D (207-386) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APOBEC3D |
| Gene ID | 140564 |
| Uniprot ID | ABC3D_HUMAN |
| Immunogen Region | 207-386 |
| Immunogen Sequence | AMYPHIFYFHFKNLLKACGR NESWLCFTMEVTKHHSAVFR KRGVFRNQVDPETHCHAERC FLSWFCDDILSPNTNYEVTW YTSWSPCPECAGEVAEFLAR HSNVNLTIFTARLCYFWDTD YQEGLCSLSQEGASVKIMGY KDFVSCWKNFVYSDDEPFKP WKGLQTNFRLLKRRLREILQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 207-386 of human APOBEC3D (NP_689639.2). |
Additional Info
| Tissue Specificity | Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung. |
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Also inhibits the mobility of LTR and non-LTR retrotransposons. (Microbial infection) Enhances hepatitis B virus/HBV replication by excluding restriction factors APOBEC3F and APOBEC3G from HBV capsids. |
| Protein Name | Dna Dc->Du-Editing Enzyme Apobec-3dA3dA3de |
| Database Links | |
| Cellular Localisation | CytoplasmP-Body |
| Alternative Antibody Names | Anti-Dna Dc->Du-Editing Enzyme Apobec-3d antibodyAnti-A3d antibodyAnti-A3de antibodyAnti-APOBEC3D antibodyAnti-APOBEC3DE antibody |
Information sourced from Uniprot.org