Anti-APOBEC3C antibody (10-90 aa) (STJ190253)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 10-90
General Information
| Short Description | Rabbit polyclonal anti-DNA dC->dU-editing enzyme APOBEC-3C (10-90 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | APOBEC3C |
| Gene ID | 27350 |
| Uniprot ID | ABC3C_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 10-90 |
| Immunogen Region | 10-90 aa |
| Specificity | ABC3C Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. |
| Protein Name | Dna Dc->Du-Editing Enzyme Apobec-3cA3cApobec1-LikePhorbolin I |
| Database Links | Reactome: R-HSA-72200Reactome: R-HSA-75094 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Dna Dc->Du-Editing Enzyme Apobec-3c antibodyAnti-A3c antibodyAnti-Apobec1-Like antibodyAnti-Phorbolin I antibodyAnti-APOBEC3C antibodyAnti-APOBEC1L antibodyAnti-PBI antibody |
Information sourced from Uniprot.org