| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Apolipoprotein A-V (30-110 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
APOA5 |
| Gene ID: |
116519 |
| Uniprot ID: |
APOA5_HUMAN |
| Immunogen Region: |
30-110 aa |
| Specificity: |
ApoA-V Polyclonal Antibody detects endogenous levels of ApoA-V protein. |
| Immunogen: |
Synthesized peptide derived from ApoA-V at the amino acid range 30-110 |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin. |
| Protein Name | Apolipoprotein A-VApo-AvApoa-VApolipoprotein A5Regeneration-Associated Protein 3 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-8963889Reactome: R-HSA-8963901 |
| Cellular Localisation | SecretedEarly EndosomeLate EndosomeGolgi ApparatusTrans-Golgi NetworkIn The Presence Of Sorl1Internalized To Early EndosomesSorted In A Retrograde Fashion To Late EndosomesFrom Which A Portion Is Sent To Lysosomes And DegradationAnother Portion Is Sorted To The Trans-Golgi Network |
| Alternative Antibody Names | Anti-Apolipoprotein A-V antibodyAnti-Apo-Av antibodyAnti-Apoa-V antibodyAnti-Apolipoprotein A5 antibodyAnti-Regeneration-Associated Protein 3 antibodyAnti-APOA5 antibodyAnti-RAP3 antibodyAnti-UNQ411 antibodyAnti-PRO773 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
